Which Genetic Test is Better Than 23 and Me?
The Great Plains Laboratory is excited to announce our brand new genetics test, GPL-SNP1000. This test is the most comprehensive test for alterations in the genetic code in the pathways that are most important for integrative medicine. This test looks at nine core groups of genes which are crucial for many different biological pathways. Previous to GPL-SNP1000, most genetic tests have only looked at a small subset of genes and very few SNPs (single-nucleotide polymorphisms). GPL-SNP1000 includes over 1,000 different SNPs and over 144 different genes ....SEE TABS BELOW FOR COMPLETE INFORMATION

Which Genetic Test is Better Than 23 and Me?

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Great Plains Labs Report & Consultation - Your Test Includes a Report from GPL - if further consultation is needed this is according to a fee schedule based on time and level of complexity
GPL-SNP1000 includes over 1000 different SNP's and over 144 different genes
GPL-SNP-1000 Genetic Test (Saliva Swab) [+$699.00]
Glyphosphate (urine test) -the world's most widely used pesticide - can be added to the SNP-1000 test at the time of the test for an additional [+$69.98]
Your Price: $0.00

LAB TESTS ARE AVAILABLE TO PATIENTS OF DR HALE ONLY
This information is for professional and patient educational use only and is not meant to diagnose, treat, cure, prevent any disease or replace traditional treatment, and has not been evaluated by the FDA
Great Plains Laboratory's GPL-SNP1000 Genetics Test versus 23 and Me
This information is for professional and patient educational use only and is not meant to diagnose, treat, cure, prevent any disease or replace traditional treatment, and has not been evaluated by the FDA

.........Versus........



The Great Plains Laboratory is excited to announce our brand new genetics test, GPL-SNP1000. This test is the most comprehensive test for alterations in the genetic code in the pathways that are most important for integrative medicine. This test looks at nine core groups of genes which are crucial for many different biological pathways. Previous to GPL-SNP1000, most genetic tests have only looked at a small subset of genes and very few SNPs (single-nucleotide polymorphisms). GPL-SNP1000 includes over 1,000 different SNPs and over 144 different genes. 

Here are the pathways it assesses:

Pathways

  • DNA Methylation
  • Oxalate Metabolism
  • Mental Disorders / SAM-E/B12 Metabolism
  • Gluten Opioid Peptide Homeostasis
  • Autism Spectrum Genes
  • P450s (cyps)
  • Cholesterol Deficiency
  • Acetaminophen Toxification/Detoxification
  • Transporters

GPL-SNP1000 will help you understand how these nine genetic pathways are performing in your patients. We specifically selected these pathways because of their importance in overall health. This test will help you understand your patients. We believe that GPL-SNP1000 is the most comprehensive genetic test available and will also provide a more economic genetic testing alternative






DNA Methylation

The methylation pathway is the complex process by which carbons are added onto folic acid and redistributed onto other compounds in the body. This pathway is responsible for the formation of methionine and thymidylate monophosphate (dTMP). These compounds play critical roles in nucleotide synthesis, neurotransmitter function, detoxification, and numerous other processes. The recycling of carbons for use in the methylation pathway is critical for cellular function. These enzymes are coded for on the end of the 21st chromosome, making them more susceptible to mutations.

Number of GenesGPL SNPs23&Me SNPs
910535


Oxalate Metabolism

Everyone obtains oxalates from three sources: liver cells (endogenously), yeast species (exogenously), and food (also exogenously). The degree to which an individual is predisposed to having adverse consequences from high levels of oxalate is influenced by their ability to metabolize oxalates. Deposition of oxalates in critical tissues such as brain and blood vessels, and the oxidative damage caused by oxalate salts can lead to symptoms of pain, nephrolithaisis, and possibly neurological symptoms.

Number of GenesGPL SNPs23&Me SNPs
5324


Mental Disorders / SAM-E/B12 Metabolism

The mental health panel identifies mutations to many of the genes that influence mental health. The enzymes in this panel either degrade or modify many different types of neurotransmitters. Mutations to these genes can cause an increased risk of developing depression, schizophrenia, anxiety, and bipolar disorder.

Number of GenesGPL SNPs23&Me SNPs
95311


Gluten Opioid Peptide Homeostasis

The gluten sensitivity panel looks at a large portion of the genes that if mutated, could lead to gluten sensitivity. Mutation in any of these genes may indicate the need to limit or eliminate gluten from the diet. Gluten sensitivity can manifest in a variety of symptoms. Many patients with autism spectrum disorder report neurological benefits upon switching to a gluten-free diet.

Number of GenesGPL SNPs23&Me SNPs
84810


Autism Spectrum Genes

Autism spectrum disorder (ASD) is a developmental disability that is characterized by unique cognitive and behavioral symptoms that vary in degrees of severity. Recently, there have been multiple studies that have identified a series of genetic mutations that are more commonly found in patients with ASD than found in the general population. If a patient has one of these mutations, it does not mean that he/she will develop ASD, but their risk for developing ASD may be higher than the general public.

Number of GenesGPL SNPs23&Me SNPs
3325233


P450s (cyps)

The cytochrome P450s are a family of monooxygenase enzymes that are expressed throughout the body, but are most prevalent in the liver. They detoxify exogenous chemicals (including medical drugs) and the metabolize endogenous chemicals including hormones, neurotransmitters, cholesterol, and vitamins. Mutations to some of the P450s could alter the appropriate dosage for many medications and could have long-term health consequences.

Number of GenesGPL SNPs23&Me SNPs
4224177


Cholesterol Deficiency (synthesis/absorption/transport)

Cholesterol is a very important molecule for the body. It is used to produce crucial hormones, vitamins, secondary messengers, and bile acids. Low values are associated with increased violent behavior, suicide, depression, anxiety, bipolar disease, Parkinsonâ€Ã¢â€žÂ¢s disease, and increased mortality from cancer. Low cholesterol values are also associated with manganese deficiency, celiac disease, hyperthyroidism, liver disease, malabsorption, and malnutrition.

Number of GenesGPL SNPs23&Me SNPs
1810122


Acetaminophen Toxification/Detoxification

Acetaminophen (Paracetamol, Tylenol) is one of the most commonly used pain relievers. Proper metabolization of acetaminophen is critical to preventing toxicity and any resulting damage. Genetic mutations that cause an increase in the metabolite NAPQI or that limit the bodyâ€Ã¢â€žÂ¢s ability to detoxify acetaminophen will make a person more susceptible to adverse effects from acetaminophen usage.

Number of GenesGPL SNPs23&Me SNPs
77232


Transporters

Transport proteins are important for shuttling molecules across cellular membranes. Mutations to transporter genes impede the ability of cells to uptake vital nutrients and export toxic substances. There are numerous diseases associated with faulty transport including Alzheimerâ€Ã¢â€žÂ¢s disease, coronary artery disease, aggressive behavior, and decreased drug efficacy.

Number of GenesGPL SNPs23&Me SNPs
1313050


Testing for GPL-SNP1000

GPL-SNP testing can identify your patientsâ€Ã¢â€žÂ¢ predisposition to the following:

  • ADHD
  • Adverse Drug Reactions
  • Allergies
  • Anxiety
  • Arthritis
  • Autism Spectrum Disorders
  • Bipolar Disorder
  • Cancer
  • Depression
  • Heart Disease
  • Osteoporosis
  • Oxidative Stress
  • Schizophrenia
  • And More