The Organic Acids Test (OAT) provides an accurate evaluation of intestinal yeast and bacteria. Abnormally high levels of these microorganisms can cause or worsen behavior disorders, hyperactivity, movement disorders, fatigue and immune function. Many people with chronic illnesses and neurological disorders often excrete several abnormal organic acids. The cause of these high levels could include: oral antibiotic use, high sugar diets, immune deficiencies, and genetic factors.
If abnormalities are detected using the OAT, treatments can include supplements, such as vitamins and antioxidants, or dietary modification. Upon treatment, patients and practitioners have reported significant improvement such as decreased fatigue, regular bowel function, increased energy and alertness, increased concentration, improved verbal skills, less hyperactivity, and decreased abdominal pain. The OAT is strongly recommended as the initial screening test.
The Microbial Organic Acids Test (MOAT) is ideal for follow-up to the OAT and is often recommended by practitioners looking for a specific abnormality, to monitor certain microbial imbalances, or to assess treatment efficacy.
"Interpretation of the Organic Acids Test" by Dr. William Shaw from The Great Plains Laboratory on Vimeo.
Join Dr. Shaw for an explanation of The Great Plains
Laboratory’s Organic Acids Test (OAT) from the creator himself.
most popular test was recently expanded to 74 markers and their OAT is
U.S. Patented, offering twice the number of markers than their
competitors. Dr. Shaw will explain this unique test in detail and review
the results of five OAT cases.
The OAT provides a metabolic “snapshot” based on the products the
body discards through the urine. These small, discarded organic acid
molecules are byproducts of human cellular activity, the digestion of
foods, and the metabolism of gastrointestinal flora. At certain levels,
organic acids in urine may be indicators of toxicity or “markers” of the
function of metabolic pathways. Levels of yeast or gastrointestinal
bacteria metabolites are compared to normal levels of human metabolites,
providing an assessment of yeast and bacterial activity.
The new and improved OAT has increased the number of tested compounds
to 74 and two new ratios have been added. The new compounds detected
may result from variations in vitamin and hormone metabolism, energy
level, intestinal wall integrity, neurotransmission, and muscle
"After identifying a low serotonin level on
an Organic Acid Test (a hallmark functional medicine test), A severely
depressed and suicidal man began taking 100mg of 5htp twice a day (5htp
is the direct precursor to serotonin). After 2 days, he said his
depression virtually disappeared and he was no longer suicidal. I love
when I can identify a biochemical glitch and someone can have such a
profound emotional turn around."
"The Organic Acids Test has brought new
meaning to my specialized practice in women's health. This test has
allowed me to investigate more deeply the chronic issues that contribute
to female related conditions like PMS, uterine fibroids, endometriosis,
chronic UTIs and vulvodynia. I have had a great deal of success in
treating complicated PMS cases that didn't respond to typical female
hormone balancing therapies. Since utilizing the OAT, it has provided me
with a variety of information to determine the underlying cause of
female related issues. Some of the markers that I find valuable for
women's health issues are the bacterial and yeast metabolites, oxalates,
B vitamins, vitamin C, and pyroglutamic acid. I have been so impressed
by this test that I can't help but want to spread the word about its
uses for various women's health conditions!"
10 mL of first morning urine before food or
drink is suggested. Patient should avoid apples, grapes (including
raisins), pears, cranberries and their juices 24 hours prior to specimen
The Microbial Organic Acids Test (MOAT) is included in the Organic Acids Test (OAT) and indicates the metabolites produced by yeast and bacteria. Elevated test values are related to yeast or bacterial dysbiosis.
This test reports 21 metabolites (including creatinine) such as markers for beneficial bacteria, harmful bacteria, Clostridia species, Candida species, yeast and fungal metabolites, and general markers of dysbiosis.
The MOAT is ideal for follow-up to the OAT and may be recommended by practitioners looking for a specific abnormality, to monitor certain microbial balances, or to assess treatment efficacy. We strongly recommend thefull OAT as the initial screening test.
"I like the work of The Great Plains Laboratory, Inc., and the book and conferences by Dr. Shaw. I have sent samples of my patients (names omitted) for detection of organic acids and morphine peptides in urine and now they are improving greatly with the results you have recommended."
– Pediatrician from Barcelona, Spain
10 mL of first morning urine before food or drink is preferred. Patient must avoid apples, grapes (including raisins), pears, cranberries and their juices 24 hours prior to specimen collection.