Enhanced Calmness Day or Night* Liposomal Zen is an advanced delivery version of our product, 200 mg of Zen.* It contains gamma-aminobutyric acid (GABA) and theanine (glutamic acid gamma-ethylamide), an amino acid derivative found naturally in green tea (Camellia sinensis). Together they help support healthy moods and a feeling of calm relaxation, whether during the day or the night.*
Liposomal Zen uses an advanced liposomal delivery system with unilamellar (single bilayer) liposomes. These are made from pure soy-free essential phospholipids obtained from sunflower seed oil lecithin. The liposomes encapsulate the ingredients inside a spherical phospholipid bilayer membrane, which allows increased direct absorption in the upper intestine.*
Research has shown that dietary components can modulate the body’s levels of neurotransmitters, e.g. serotonin, dopamine, norepinephrine, and GABA. Alterations in the levels of these neurotransmitters, perhaps induced by metabolic stress or vitamin deficiencies, e.g. vitamin B6, can significantly influence mood and emotional status, as well as motor function.* GABA is the major inhibitory neurotransmitter in the brain and is active at 20% of central nervous system synapses. GABA, via its neuronal A receptor, inhibits neurons by causing an influx of chloride ions. This chloride influx initiated by GABA is known to be part of the bodily mechanisms involved with mood, muscle relaxation and sedation.* A decrease in GABA’s function as an inhibitory mediator or a dysregulated sensitivity of GABA receptors can lead to excessive neuronal activity.* Theanine is also recognized to have calming properties.*
Theanine offers a unique combination of properties, allowing it to help relieve occasional sleeplessness, and at other times to help restore calm alertness when experiencing fatigue or drowsiness.* Human studies have demonstrated that oral theanine supplementation increases alpha wave activity, fostering a state of calm relaxation.* Theanine also supports a normal, healthy attitude during premenstrual syndrome, and diminishes the normal symptoms of PMS.*
Liposomal Zen uses only Suntheanine®, pure L-theanine from Taiyo International, Inc. Item #76810 50 mL (1.7 fl. oz.) (Hypoallergenic) AllergyResearchGroup Innovative Nutrition *THIS STATEMENT HAS NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.
April – 2014 References Allergy Research Group, LLC 2300 North Loop Road, Alameda, CA 94502 Phone: 800-545-9960 or 510-263-2000 Fax: 800-688-7426 or 510-263-2100 www.AllergyResearchGroup.com Timmcke JQ, Juneja LR, Kapoor MP. FASEB J. April 2008 22 (Meeting Abstract Supplement) 760. Ueda T, Ozeki M, Okubo T, Chu D, Juneja LR, Yokogoshi H, Matsumoto S. JSPOG J. Vol. 6, No. 2, pp 234-239, December 2001.Anderson IM, Mortimore C. Adv Exp Med Biol 1999;467:43-55. Benton D, Donohoe RT. Public Health Nutr 1999;2:403-9. Eghbali M, Curmi JP, Birnir B, et al. Nature 1997;388:71-5. Goddard AW, Mason GF, Almai A, et al. Arch Gen Psychiatry 2001;58:556-61. He P, Wada S, Watanabe N, et al. J of Food Sci, 2000;65:30-33. Juneja L, Chu D, Okuba T. Trends Food Sci Tech 1999;10:199- 204. Kakuda T, Nozawa A, Unno T, et al. Biosci Biotechnol Biochem 2000;64:287-93. Kakuda T, Yanase H, Utsunomiya K, et al. Neurosci Lett 2000;289:189-92. Kimura R, et al. Chem Pharm Bull (Tokyo) 1986;34:3053-7. Lombard CB. Med J Aust 2000;173 Suppl:S104-5. Markus CR, Panhuysen G, Tuiten A, et al. Appetite 1998;31:49-65. Moore P, Gillin C, et al. Arch Gen Psychiatry 1998;55:534-9. Paul SM, Marangos PJ, Skolnick P, et al. Encephale 1982;8:131-44. Paz A, Berry EM. Ann Nutr Metab 1997;41:291-8. Petty F, Trivedi MH, Fulton M, et al. Biol Psychiatry 1995;38:578-91. Prasad C. Braz J Med Biol Res 1998;31:1517-27. Sadzuka Y, Sugiyama T, Sonobe T. Toxicol Lett 2000;114:155-62. Shiah IS, Yatham LN. Life Sci 1998;63:1289-303. Sugiyama T, Sadzuka Y. Cancer Lett 1998;133:19-26. Sugiyama T, Sadzuka Y, Tanaka K, et al. Toxicol Lett 2001;121:89-96. Sundstrom I, Ashbrook D, Backstrom T. Psychoneuroendocrinology 1997;22:25-38. Unno T, Suzuki Y, Kakuda T, et al. J Agric Food Chem 1999;47:1593-6. Verger P, Lagarde D, Batejat D, et al. Physiol Behav 1998;64:317- 22. Vescovi PP, Volpi R, Coiro V. Alcohol 1998;16:325-8. Wells AS, Read NW, Laugharne JD, et al. Br J Nutr 1998;79:23- 30. Yokogoshi H, Kato Y, et al. Biosci Biotechnol Biochem 1995;59:615-8. Yokogoshi H, Kobayashi M. Life Sci 1998;62:1065-8. Yokogoshi H, Mochizuki M, Saitoh K. Biosci Biotechnol Biochem 1998;62:816.
Serving Size: 4 Pumps (2 mL) Servings Per Container: 25 Amount Per Serving: GABA (Gamma-Aminobutyric acid) 150 mg L-Theanine 100 mg Phospholipids (from Sunflower Lecithin) 200 mg Other ingredients: Water, glycerin, ethanol, d-alpha tocopheryl polyethylene glycol 1000 succinate.
Suggested Use: As a dietary supplement, 1 to 4 pumps one or two times daily between meals, or as directed by a healthcare practitioner. Warning: If taking antidepressants or other psychotropic medications, use only under the supervision of a qualified healthcare practitioner. Although we are not aware of any interactions, because these also affect brain function there is theoretical potential for negative or positive interactions, either of which would need to be monitored. Store in a cool, dry place. May be refrigerated for longer term storage. Contains Suntheanine®, pure L-theanine from Taiyo International, Inc.