THE DETOX QUBE- The Three-Part System for Successful Detoxification - 3 Mo. Supply
This kit contains enough products to last for a full 3 months - SEE INFO ON THE PRODUCTS CONTAINED IN THIS KIT BELOW -The Three-Part System for Successful Detoxification - See the Whole Body Cleanse and Detoxification TAB below for more info
This kit was designed to make it easy to get started on the IMD Detox Program (Intestinal Metals Detox).
This kit contains enough products to last for a full 3 months.
The IMD and Clearway Cofactors come in a larger size in this kit only.
These larger sizes cannot be ordered individually.

Whole Body Cleanse and Detoxification: THE DETOX QUBE

The Quicksilver Detox Qube contains all the elements necessary for systemic glutathione system support to enable natural detoxification. This bundle of specifically selected products is designed according to a "protocol" and meant to be exactingly followed for maximum effect. It's meant to lower metal burdens by strengthening the glutathione system, which enables natural detoxification at the cellular level. And the liposomal delivery of these beneficial compounds will also support natural, optimal health, by increasing bioavailability and nourishing cell for a whole body cleanse.

Follow the Qube protocol to complete any of Dr. Shade's "Three levels of Detox." Each successive level uses higher dosing than the previous, as such the Qube contents are consumed in shorter time for each level. Levels should be completed in sequence. (The protocols here are only suggested dosages and timings. Please verify this protocol with your healthcare practitioner. This system is not intended to diagnose or treat any disease, but is designed to support your body's natural antioxidant and detoxification system functions.)

This kit contains: 1 bottle of IMD powder (9 grams)
2 bottles of Clearway Cofactors (120 caps)
6 50-ML bottles of Etheric Delivery Liposomal Vitamin C w R-Lipoic Acid
6 50-ML bottles of Etheric Delivery Liposomal Glutathione

  • Level 1 takes 3 months to complete the Qube
  • Level 2 takes 2 months to complete the Qube
  • Level 3 takes 1.5 months to complete the Qube
  • THE DETOX QUBE- The Three-Part System for Successful Detoxification - 3 Mo. Supply

    Your Price: $795.00
    In Stock
    Part Number:QUBE

    New Customers Please Register (Create a New Account) or Existing Customers Please Login

    Click Here to Login to your account or Click Here to Create Your Account.

    Consultation for first time customers interested in purchasing this Brand of Products is required. Please call during office hours - 561-337-9435 (an initial 10 min consultation is complimentary)
    IF you already have a prescribing practitioner, please have your practitioner send a note authorizing purchase to: Dr. Hale, AP at acudocpb@gmail.com or fax: 855-486-6426
    If you do not have a prescribing practitioner, then Dr. Hale, AP will be glad to be of assistance.
    This is a professional brand product and as such there are internet sales restrictions per the manufacturer's policies.

    Please introduce yourself by filling out our very basic Wellness Questionnaire by Clicking Here (This is by no means a medical history....just a conversation opener)

    Thank you for your interest

    Dr Hale, AP

    Choose Options

    Add EDTA to this order
    ADD 2 x Etheric Delivery EDTA (4 oz.) to the Detox Qube [+$100.00]
    Other Optional Additions to the Qube Kit
    Ayush Herbs Rentone 2 90-cap bottles [+$66.00]
    Quinton Isotonic 4 30-vial boxes [+$208.00]
    Quinton Hypertonic 1 30-mL Box [+$52.00]
    Multimineral (e.g., Pure Encapsulation Mineral 650) 2 bottles of 180 Caps [+$49.89]
    Multimineral w/0 Cu & Fe (e.g., Pure Encapsulation Mineral 650) 2 bottles of 180 Caps [+$50.39]
    Zinc 15 (15mg/day) 60 caps 15-mg [+$9.90]
    Zinc 30 (30mg/day) 60 caps 30-mg [+$12.30]
    Zinc 15 (15mg/day) 180 caps 15-mg [+$25.00]
    Zinc 30 (30mg/day) 180 caps 30-mg [+$30.50]

    YOU MUST LOGIN TO PURCHASE

    CONSULTATION REQUIRED

    Home Pg ID:

    11
     photo DetoxQube_large-small.jpg
    This kit was designed to make it easy to get your patients started on the IMD Detox Program. This kit contains enough products to last for a full 3 months. The IMD and Clearway Cofactors come in a larger size in this kit only. These larger sizes cannot be ordered individually. This kit contains: 1 bottle of IMD powder (9 grams) 2 bottle of Clearway Cofactors (120 caps) 6 bottles of Etheric Vitamin C with R-Lipoic Acid, 6 bottles of Etheric Glutathione

    1 x 9mg IMD  (Intestinal Metals Detox Protocol)

    2 x Clear Way Cofactor(120 count)

    6 x Etheric Delivery Glutathione (50ml)

    6 x Etheric Deliver Vitamin-C w/ Na-R-Lipoic Acid (50ml)

    Includes a Complete Protocol Instructions for:

    Level 1 (3 months)

    Level 2 ( 2 months)

    Level 3 (1.5 months)


    ***Temperature Sensitive Product***

    Please note the price of this product includes the ice packs and other materials required for shipping. As an additional measure, we do not ship any cold products (e.g. probiotics) on a Thursday or Friday to avoid potential prolonged heat exposure. UPS 2nd Day Air Required on all items from April-October. Next Day Air may be required if shipping to: AZ, NM, NV, TX, LA, AL, MS, FL, GA. During summer months, certain cold ship orders may require an additional fee for insulated shipping boxes. We will contact you prior to shipment to update your quote.


    Details

    The Quicksilver Detox Qube contains all the elements necessary for systemic glutathione system support to enable natural detoxification. This bundle of specifically selected products is designed according to a "protocol" and meant to be exactingly followed for maximum effect. It's meant to lower metal burdens by strengthening the glutathione system, which enables natural detoxification at the cellular level. And the liposomal delivery of these beneficial compounds will also support natural, optimal health, by increasing bioavailability and nourishing cell for a whole body cleanse. Follow the Qube protocol to complete any of Dr. Shade's "Three levels of Detox." Each successive level uses higher dosing than the previous, as such the Qube contents are consumed in shorter time for each level. Levels should be completed in sequence. (The protocols here are only suggested dosages and timings. Please verify this protocol with your healthcare practitioner. This system is not intended to diagnose or treat any disease, but is designed to support your body’s natural antioxidant and detoxification system functions.)

    Dosage

    The box comes with dosage instructions.


    IMD INTESTINAL CLEANSE  (Intestinal Metals Detox Protocol)  

    Heavy Metal Detox : Bind Those Metals!
    IMD Heavy Metal Detox

    Quicksilver Scientific’s sophisticated detoxification supplement, IMD Intestinal Cleanse optimizes the natural removal of metals through the intestines. This proprietary compound supplements the natural action of glutathione in the intestines. IMD delivers insoluble thiol groups to bind and remove heavy metals accumulated in the intestines and to directly quench freeradicals. IMD’s actions enhance Phase III Detoxification—the system of transporters leading out of the body.
    Recommended Usage: Begin with one–half scoop for 3 days to test tolerance. Once tolerance is established, use one full scoop per day in 4–6 oz water with 2–6 pumps Etheric Delivery Vitamin C with R-Lipoic Acid or other source of soluble vitamin C. Alternatively, the product combines well with Etheric Delivery EDTA with R-lipoate. Slowly titrate up the dose over several months to three or four doses per day. Use product in cycles of 5-days-on/2-days-off or 10-days-on/4-days-off.  Some very sensitive individuals need to start with even less than one-half scoop.

    1. Summary
    Quicksilver Scientific has developed an innovative supplement product known as IMD (Intestinal Metals Detox), designed to promote the safe and effective therapeutic detoxification of mercury and other toxic metals from the body. This proprietary compound "reboots" and optimizes key biological detoxification processes for the safe removal of metals through the intestines and reduces the liver and kidney stress common with pharmaceutical chelation therapy. IMD optimizes the natural action of glutathione in the intestines by using insoluble thiol groups to bind and remove heavy metals accumulated in the intestines and to directly quench free-radicals. 

    Quicksilver Scientific’s sophisticated detoxification supplement, IMD Intestinal Cleanse optimizes the natural removal of metals through the intestines. This proprietary compound supplements the natural action of glutathione in the intestines. IMD delivers insoluble thiol groups to bind and remove heavy metals accumulated in the intestines and to directly quench free radicals. IMD’s actions enhance Phase III Detoxification—the system of transporters leading out of the body.

    • Binds mercury and other heavy metals in the intestines and escorts these harmful contaminants out of the body.
    • Intercepts methyl mercury and other metals trapped in enterohepatic circulation. Facilitates heavy metal detox, binding and removing intestinal heavy metals.
    • Leads to lowering of blood mercury levels, allowing organ- and tissue-bound mercury safely to drain into the blood at a natural rate.
    • Improves the body’s natural detoxification ability by quenching free radicals and stopping metal-catalyzed freeradical reactions that can lead to inflammation and cause down-regulation of detox transporters (Phase III transporters—OATs, cMOAT, MRPs, etc).1
    • Fortifies the link between the intestines and the immune system.
     Active Chemistry of IMD

    IMD (Intestinal Metals Detox) is a proprietary product that consists of highly purified silica with covalently attached thiolic metal-binding groups. Both the silica base and the binding agents are GRAS (Generally Recognized as Safe) for use in food. The specific chemistry of the compound has several benefits over other detoxification remedies, specifically heavy metal detox.

    • The active binding groups out-compete other compounds for metals in the intestines.
    • Because IMD Intestinal Cleanse does not enter the bloodstream, it will not lead to redistribution or surges of mobilized metals that can lead to potential kidney/liver overload. In fact, preliminary data suggests increased liver function in some patients, as measured by changes in bilirubin levels.
    •  Eliminates Disruptions in Natural Body–Wide Detoxification

    Eliminates Disruptions in Natural Body-Wide Detoxification

    Intestinal inflammation inhibits elimination of toxins by causing a strong down-regulation of the body's natural detoxification pathways. Ironically, exposure to certain toxins contributes to intestinal inflammation. For example, the corrosion of "silver" dental amalgam alloy results in mercuric mercury (Hg) release. When swallowed with saliva, Hg can cause intestinal inflammation and initiate this negative feedback.
    In addition to inflammation, it has been demonstrated that a build up of metals alone slows the transport proteins.3 The data suggests that continuous removal of metals from the intestines is essential for the proper daily functioning of natural detoxification processes. The continuous removal of metals is also critical for a successful practitioner-directed detoxification program.

    Healthy Detoxification ( See Figure 1, below)

    Detoxification processes occur throughout the body. A healthy detoxification pathway typically involves three phases. Phase I involves oxidative activation of a toxin. This prepares the toxin for conjugation to a hydrophilic bio-molecule in Phase II. The conjugate is then moved through a series of Phase II transporters, leading to intestinal or kidney excretion.


    Impaired Detoxification (Figure 1, below)

    Intestinal inflammation disrupts detoxification in two ways.

    Inhibiting the conjugation of toxins throughout the body and inhibiting transport of toxins into the intestines. Intestinal inflammation down-regulates Phase II transporters. When transporters down-regulate, Phase I activity, which is coupled to Phase III, is also turned down. Phase I activity, however, does not get down-regulated. Phase I oxidation continues but is no longer coupled to Phase I conjugation.
    Inhibiting glutathione activity in the intestines. Phase II transporters bring glutathione (GSH) into the intestines from the liver. GSH is the primary anti-oxidant for quenching free-radical reactions in the intestines. A deficiency of GSH is a symptom of inflammatory bowel diseases, including Crohn's Disease. Thus down-regulation of Phase II transporters can be self-propagating as oxidative stress stops the flow of this crucial antioxidant.

    • Recent research at the Nestle Cancer Center in Switzerland examined genetic expression of the body's detoxification pathways and found that the small intestine and the liver work together to coordinate detoxification and metabolism. The Nestle Center also found that glutathione activity is predominantly modulated from the small intestine. This finding supports our model of Phase II transporters in the intestines controlling Phase I pathways and points to the centrality of the intestines in any detoxification protocol.
    Intestinal inflammation inhibits elimination of toxins by causing a strong down-regulation of the body’s natural detoxification pathways.
    1 Ironically, exposure to certain toxins contributes to intestinal inflammation. For example, the corrosion of amalgam mercury results in mercuric mercury (HgII, also called inorganic mercury) release. When swallowed with saliva, HgII can cause intestinal inflammation and initiate this negative feedback.

    2 In addition to inflammation, it has been demonstrated that a build up of metals alone slows the transport proteins.

    3 The data suggests that continuous removal of metals from the intestines is essential for the proper daily functioning of natural detoxification processes. The continuous removal of metals is also critical for a successful practitioner-directed detoxification program.

    Data Supporting IMD Safety and Efficacy

    Historical Use of Insoluble Thiolated Compounds

    The concept of an IMD-type product is not entirely new. It was successfully tested and used in the 1970's. However, absorbable chelators such as DMSA and DMPS received greater clinical exposure and were adopted by the medical community during the 1980's and 90's. The most researched version of an IMD-type product used in the 1970's took the form of thiolligand attached to a polymer backbone (polystyrene-divinyl-benzene - a polymerized organic solvent similar to toluene). This thiolated polymer resin (termed polythiol resin) was well-researched to prove safety and efficacy in animal and human studies. In fact, it was used during a mercury poisoning outbreak in Iraq. The Quicksilver innovation of a silicon dioxide (same formula as quartz) backbone for IMD provides a much more natural substrate for the human body that will not provoke a reaction from the immune system in the gut. Potential toxicity will be due to the thiol groups more than the backbone, so the toxicity studies on the polythiol resin outlined below apply to IMD.


    Animal Safety Study

    A safety study was conducted in 1973 by Schwetz et al. to evaluate the effects of the polythiol resin on embryonal, fetal and neonatal development in rats. The study evaluated doses of 150 and 1500 mg/kg/day (administered at various time periods to evaluate different periods of development). Assuming a 75 kg human, this is 11,250 mg per day at the low dose and 112,250 mg per day at the high dose. A normal dose of IMD is 100-200 mg and the density of silica is roughly 2X that of the polymer resin. A polymer resin has roughly 2X the amount of thiols per weight due to its higher volume, so 100mg of IMD has the equivalent volume and equivalent amount of thiol as 50mg polythiol resin. This makes the low dose of the safety study ~220 times the lower normal dosage of IMD and the high dosage in the study ~2200 times the lower normal dose of IMD. Despite the high dosing, the 150mg/kg/day dosage showed "no effect on the developing embryo, fetus, or neonate." The high dosing (2200X our dosing rate) showed some delay in ossification of skull bones but no teratogenic effects. Some effect is not surprising at this high dose.


    Animal Efficacy Study

    Effectiveness of the polythiol resin at lowering body burden of mercury was evaluated in a feeding trial where mice were injected with methylmercury and then fed a control diet or the same diet with polythiol resin added to it. After 42 days of resin treatment, mercury levels in blood, brain, kidney and liver had been reduced by a factor of 7.2,6.0,7.2 and 10.0 respectively. The comparison between treated and untreated animals is highlighted in the reproduced table below.

    The reduction in organ levels points to the rapid redistribution of methylmercury that occurs throughout the body. The mechanism of cleaning the blood through the intestines leads to efficient lowering of organ burdens as well.


    The study also found that the resin reduces absorption of mercury in the diet by 50%, which has profound implications for prophylaxis of people with high-fish diets.


    Human Use for Iraq Methylmercury Poisoning

    The polythiol resin was used to treat human subjects during the methylmercury poisoning outbreak of 1971-72, where homemade bread was made from wheat treated with a methylmercury fungicide. 11 The efficacy was judged against absorbable chelators DMPS (dimercapto propane sulfonate), PEN (D-penicillamine), and NAP (n-acetyl-DL-penicillamine). The results (reproduced at left) showed a -3-fold lowering of methylmercury of the animal study, we can presume that this lowering of life in the blood. Based on the findings methylmercury also occurs in the brain/organs. The polythiol resin outperformed PEN and NAP. It also compared favorably with DMPS (the most powerful, but also the most aggressive and potentially nephrotoxic mercury chelator).


    Recent Results with Silica-based Thiol - IMD

    Small-scale clinical trials and case studies with IMD provide results consistent with the Iraq polythiol trial, however at a ~10 to 100 fold lower dosage. Iraq poisoning dosage ranged from 2,250 to 16,500 mg/day for a 75-kg person. Typical IMD use is only 100-200mg/day. This increase in efficacy is made possible by the unique proprietary thiol group linked to the silica particle.


    Half-life Lowering with IMD.

    Half-life of MeHg was measured after a single dose of high-Hg fish. With a dosage of 200mg/day of IMD, the half life was measured at 17 days and the time back to baseline at 40 days. This compares with an untreated half-life of 60 days and a polythiol resin treatment half-life of 19 days (Iraq study). A study of fish-mercury half-life done by Clarkson 12 shows a half-life of 44-64 days and a time to baseline of 160 days after a single dose of high-Hg fish. IMD is showing a roughly 4 fold increase in depuration rate in comparison to no treatment.


    Short-Term Clinical Use

    Small-scale clinical trials were conducted with patients undergoing dental amalgam revision. In Clinic 1, after 7-10 days of treatment with IMD, patients experienced an average 23.9% decrease in total blood mercury (Table 1 at left). Very little change is seen in people who did not use IMD. This period of rapid decay in blood level is usually followed by a slower decay as the body re- equilibrates and releases mercury from both intracellular and extracellular spaces into the blood.


    Long-term Use - Case Studies

    Long-term data from Dr. Christopher Shade shows that IMD use combined with dental revision steadily decreases methyl (MeHg) and inorganic mercury (Hg) blood levels over a period of months. Blood Hg shows a two-phase reduction featuring a rapid initial decrease followed by slower decrease (Figure 2). Fecal excretion data (not shown) reveals release and excretion from bodily stores (from 1/30th to 1/10th of the blood burden of MeHg excreted per day). Blood MeHg levels constantly equilibrate with (and track) the body burden, which is consistent with other reports.

    These decreases are especially significant when comparing these results to a large-scale baseline study of patients undergoing dental revision without any detoxification. This study showed that total blood mercury levels did not decrease following revision. Dental revision actually promoted an increase in MeHg over time (Figure 3), whereas patients who did not undergo dental revision had stable levels of blood MeHg and Hg. The increase in blood MeHg after revision is consistent with our model: Following removal of the intestine's irritating mercury source (i.e. amalgam), activity of Phase I enzyme Glutathione S-Transferase increases and moves mercury out of cells into the bloodstream. Unfortunately, enterohepatic circulation prevents it from leaving the body.

    Other Long-Term Case Studies:

    Several hundred patients have now used IMD during long-term detoxification. Monitoring data from three of the initial patients is shown to the left.


    Patient #1 was a long-time fish consumer that had amalgams for most of her life - they were removed several years before the detox. She ceased fish consumption during the detox and her MeHg levels fell -70% over three months.


    Patient #2 still had dental amalgams and ate a lot of fish. He neither removed his amalgams nor ceased fish consumption, yet still managed to have a 30% decrease in MeHg over 6 months of use.


    Patient #3 had amalgams and ate large amounts of tuna salad. With removal of his amalgams and cessation of fish consumption, he achieved an 80% removal of MeHg and 90% removal of Hgl/ in 6 months.


    Evidence for Opening of Phase II Transporters with IMD

    Bilirubin is a by-product of hemoglobin breakdown. Accumulation of bilirubin in the blood is the cause of jaundice and is generally considered to be a sign of poor liver function. Extensive experimentation demonstrates that the major problem associated with bilirubin excretion is the failure of Phase II transporters to move the conjugated bilirubin from the liver into the intestines. This is the same transporter that moves glutathione and glutathione conjugates (including mercury glutathione) into the intestines and sulfate conjugates into the urine. There is abundant anecdotal evidence of a connection between mercury toxicity and bilirubin buildup. This anecdotal connection is seen on Gilbert Syndrome Web Forums, where flare-ups of GS are cited after amalgam placements or unprotected amalgam removals.

    In the IMD trials conducted on patients with recent dental revision, there has been rapid and dramatic lowering of blood bilirubin in those with elevated levels of this compound. This data supports the model demonstrating that IMD opens Phase II transporters and consequently up-regulates Phase /I conjunctions. According to the model, Phase II transporters up-regulate as a result of the reduced amount of inflammation and toxic metals present in the gut.
    Because of these broad-spectrum effects on the whole detoxification system, many practitioners are using IMD outside the scope of metals-specific detoxification. IMD is now becoming an important component in whole-body/general detoxification protocols.


    DISCLAIMER

    Quicksilver Scientific does not imply that IMD will cure any disease. This document is designed to aid health practitioners by synthesizing multiple studies on human detoxification pathways. Cited references and further information on our clinical studies, received testimonials and plans for future studies are available upon request.


    Cited Literature:

    1. Kalitsky-Szirtes, J.; Shayeganpour, A.; Brocks, D. R; Piquette-Miller, M., Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats. Drug Metabolism and Disposition 2004,32, (1),20-27.
    2. Nadarajah, V.; Neiders, M. E.; Aguirre, A; Cohen, R E., Localized cellular inflammatory responses to subcutaneously implanted dental mercury. Journal of Toxicology and Environmental Health 1996, 49, (2), 113-126(14).
    3. Cnubben, N. H. P.; Rietjens, I. M. C. M.; Wortelboer, H. M.; van Zanden, J.; van Bladeren, P. J., The interplay of glutathione-related processes in antioxidant defense. Environmental Toxicology and Pharmacology 2001, 10, 141-152.
    4. Oude Elferink, R J. P.; OUenhoff, R; Liefting, W.; de Haan, J.; Jansen, P., L.M., Hepatobiliary transport of glutathione and glutathione cojugate in rats with hereditary hyperbilirubinemia. Journal of Clinical Investigation 1989, 84, 476-483.
    5. Martensson, J.; Jain, A; Meister, A., Glutathione is required for intestinal function. Proceding of the Natural Academy of Sciences 1990, 87, 1715-1719.
    6. Sido, B.; Hack, V.; Hochlehnert, A; Lipps, H.; Herfarth, C.; Droge, W., Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut 1998, 42, 485-492.
    7. Ruemmele, F. M.; Bier, D.; Marteau, P.; Rechkemmer, G.; Bourdet-Sicard, R; Walker, W. A; Goulet, 0., Clinical evidence for immunomodulatory effects of probiotic bacteria. Journal of Pediatric Gastroenterology and Nutrition 2009, 48, 126-141.
    8. Much, D. M.; Crespy, V.; Clough, J.; Henderson, C. J.; Lariani, S.; Mansourian, R; Moulin, J.; Wolf, R; Williamson, G., Hepatic cytochrome P-450 reductase-null mice show reduced trascriptional response to quercetin and reveal physiological homeostasis between jejunum and liver. American Journal of Physiology - Gastrointestinal and Liver Physiology 2006,291, G63-G72.
    9. Schwetz, BA; Spencer HC; Gehring PJ, A study of prenatal and postnatal toxicityof a sulfhydryl resin in rats. Toxicology and Applied Pharmacology 1974,27,621-628.
    10. Clarkson, TW; Small, H; Norseth, T, Excretion and absorption of methyl mercury after polythiol resin treatment. Archives of Environmental Health 1973, 26, 173-176.
    11. Clarkson, TW; Magos, L.; Cox, C.; Greenwood, MR; AMin-Zaki, L; Majeed, MA; AI-Damluji., K; Test of efficacy of antidotes for removal of methylmercury in human poisoning during the Iraq outbreak. Journal of Pharmacology and Experimental Therapeutics 1981, 218, (1), 74-83.
    12. Kershaw, TG; Dhahir, PH; Clarkson, TW, The relationship between blood levels and dose of methylmerucry in man. Archives of Environmental Health 1980, 35(1),28-36.
    13. Berglund, F; Berlin, M, Risk of methylmercury cumulation in man and mammals and the relation between body burden of methyl mercury and toxic effects, in Miller M, Berg GG (eds): Chemical Fallout. Springfield, IL, Charles Thomas Publisher, 1969, p. 258.
    14. Halbach, S.; Vogt, S.; Kohler, W.; Felgenhauer, N.; Welzl, G.; Kremers, L.; Zilker, T.; Melchart, D., Blood and urine mercury levels in adult amalgam patients of a randomized controlled trial: Interaction of Hg species in erythrocytes. Environmental Research 2008,107,69-78.
    15. Wortelboer, H. M.; Balvers, M. G. J.; Usta, M.; van Bladeren, P. J.; Cnubben, N. H. P., Glutathione-dependent interaction of heavy metal compounds with multidrug resistanc proteins MRP1 and MRP2. Environmental Toxicology and Pharmacology 2008,26, 102-108.
    16. Ng, K. H.; Lim, B. G.; Wong, K. P., Sulfate conjugating and transport functions of MOCK distal tubular cells. Kidney International 2003, 63, 976-986. 
     

    Recommended Usage: Begin with one–half scoop for 3 days to test tolerance. 

    Once tolerance is established, use one full scoop per day in 4–6 oz water

    with 2–6 pumps Etheric Delivery Vitamin C with R-Lipoic Acid or other source of soluble vitamin C. 

    Alternatively, the product combines well with Etheric Delivery EDTA with R-lipoate. 

    Slowly titrate up the dose over several months to three or four doses per day. 

    Use product in cycles of 5-days-on/2-days-off or 10-days-on/4-days-off.  

    Some very sensitive individuals need to start with even less than one-half scoop.

    Drug Metabolism and Disposition 2004, 32, (1), 20-27.
    Journal of Toxicology and Environmental Health 1996, 49, (2), 113-126(14).
    Interaction of heavy metal compounds with multidrug resistant proteins MRP1 and MRP2. Environmental Toxicology and Pharmacology 2008, 26, 102-108.


    Clear Way Cofactors Phytonutrient Antioxidant Blend - 75 capsules... info 

    Quicksilver Scientific Clear Way Cofactors Proprietary blend of phytoextracted polyphenolics, sodium buffered R-Alpha Lipoic Acid, targeted vitamins, selenium, standardized kelp extract and Lumbrokinase designed to maximize metal detoxification pathways.

    Epicatechin 
    The Clear Way Cleanse Cofactors is a is a proprietary blend of phytoextracted polyphenolics, sodium buffered R-Alpha Lipoic Acid (Na-RALA), targeted vitamins (B1, B5, B6), selenium, standardized kelp extract and high-potency Nattokinase designed to maximize metal detoxification pathways. The polyphenolics and Na-RALA have demonstrated the ability to upregulate the detoxification systems of the body, especially the glutathione system, through stimulation of the Nrf2/antioxidant response element pathway. Furthermore many of the highest-content ingredients (Haritaki, Pine Bark Extract, R-lipoic acid, and Gotu Kola) have been shown to have radioprotective effects.

    The glutathione system contains multiple molecules and enzymes that function to quench oxidative stress, repair damaged proteins and detoxify/remove endogenous (internally created) and exogenous (externally acquired) toxins. The only way to truly optimize the function of the glutathione system is to stimulate the production of the system componnets from within the cells. Polyphenolic antixoidants such as Epicatechin (found in pine bark and green tea extracts), have demonstrated tremendous efficacy in doing this by "turning on" a cellular master switch called the Nrf2 protein. This protein turns on the cellular production of several antioxidants and detoxification molecules. Polyphenols have the added benefits of high anti-inflammatory properties, anticarcinogenic activity and passage through the blood-brain barrier.


    Clear Way Cofactors features highly concentrated extracts of:

    • Haritaki is the polyphenolic-rich fruit of the Terminalia Chebula tree. Haritaki is widely used in Ayurvedic medicine where it is held sacred to Shiva. It is pictured as the quintessential healing plant by the Medicine Buddha in Tibet, where Haritaki is called "The King of Herbs." Haritaki was recently shown to have extraordinary effects on the antioxidant and detoxification systems.
    • Pine Bark Extract is the richest source of epicatechins (the building block of Of'C's - oligomeric proanthocyanidins) and powerful anti-inflammatory, cardioprotective glutathione bullders. Also used for GSH system support and protection and repair from solar radiation.
    • Pomegranate Extract, a rich source of ellagic acid, which has shown impressive activity on glutathione synthesis and glutathione S-transferase octivity.
    • Gotu Kola Extract is added for nerve protection and has been shown to protect against gamma-radiation induced damage to both DNA and membranes.
    • Dandelion Extract is added for liver protection and to stimulate adequate bile and urinary flow.Kelp Extract is added for iodine/other trace minerals and polyphenolic content.
    • R-Lipoic Acid - this potent antioxidant confers both water-based (cytoplasm) and lipid-based (cell membrane) protection that is essential to full protection from radiation damage. Additionally it has tremendous impact on mitochondrial integrity.

    Nattokinase and Biofilms:

    In addition to the comprehensive cellular protection delivered by the antioxidant components of the formula, high-potency Lumbrokinase is included to help break down biofilms in the gut. These biofilms prevent detoxification and absorption of nutrients as well as lock in dysbiotic intestinal flora. Additionally, Lumbrokinase has well documented circulation benefits in patients with ischemic conditions. It has the unique quality of possessing strong anti-coagulative properties without the risk of uncontrolled bleeding. The fibrinolytic activity of Nattokinase (the strongest of all fibrolytic enzymes) will provide a significant edge in the fight against toxin accumulation and subsequent bodily degeneration. For safety, DO NOT give this supplement to patients with hemolytic conditions.

    ClearWay Cofactors is a proprietary mixture of high-potency polyphenolic antioxidant phytonutrients, R-Lipoid Acid, Kelp, and B Vitamins designed to support the body’s natural antioxidant and detoxification systems. Dr. Chris Shade specifically created this formula to help reduce any side effects from detoxification. This product can also be used for immune support.

    Haritaki is the powerhouse polyphenolic-rich fruit of the Terminalia Chebufa tree. Haritaki is widely used in Ayurvedic medicine where it is held sacred to Shiva. It is pictured as the quintessential healing plant in depictions of the Medicine Buddha in Tibet, where Haritaki is called 'The King of Herbs." Haritaki has been shown to have extraordinary effects on the antioxidant5 and detoxification systems", especially glutathione pathways, through an Nrf2-like pathway and to confer protection against radiation-induced DNA strand breaks.


    Supplement Facts

    Serving Size: 3 Capsules
    Servings Per Container: 25
    Amount Per Serving
    Thiamin (vitamin B1 as thiamine hydrochloride) 100 mg
    Vitamin B6 as pyridoxine 50 mg
    as pyridoxal 5-phosphate  15 mg

    Pantothenic acid (Vitamin B5 as calcium pantothenate) 100 mg
    Selenium (as selenomethionine) 200 mcg

    Proprietary Blend
    1405mg
    Proprietary Blend contains: Haritaki (Terminalla chebula) fruit extract, Dandelion (Terazacum offinale) root extract, Bacopa monniera leaf extract, Bladderwrack (Fucus vesiculosus) whole plant extract, Gotu Kola (Centerllla asiatica) whole plant extract, Nattokinase (soy bean fibrinase, min 20,000 fu/gram), Pine bark extract (Pinus massoniana), R-Lipoic Acid, and Quercetin.
    Other Ingredients: Vegetable capsule, silicon dioxide

    Dosage and Use:

    Take 3 capsules per day. Start with 1 capsule and increase dosage gradually. Advanced doses of 6-9 capsules per day can be used for short periods of time. Best taken on an empty stomach. If stomach becomes upset, take with meals. Take separately from the IMD.

    Quicksilver Dosage Protocol:

    Quicksilver Therapeutic Detox Dosage Level 1:
    Days "On" is typically 5 days per week, usually M-F

    Morning

    On rising

    1/2 or 1 scoop IMD in 4-6 oz water with 2 pumps Etheric Vitamin C with R-Lipoic Acid

    10-15 min later

    2 or 3 caps Clear Way Cofactors and 2 pumps Etheric Glutathione

    Lunch Time

    Lunch

    Mineral supplements as needed

    Dinner Time

    30 min before dinner

    2 pumps Etheric Vitamin C with R-Lipoic Acid and 2 pumps Etheric Glutathione (or can be done before bed)

    Days "Off" is typically 2 days off for Level 1, usually Sat-Sun

    Take a Multimineral according to directions at full or higher dosage and consider an extra 15-30 mg of Zinc

    Note: All timing blocks are flexible (e.g. If there is fatigue, try taking the "On rising" supplements at night.). If Clear Way gives any upset stomach, take with meals. If taking Rentone, take 2-3 per day in divided doses with meals.



    Quicksilver Therapeutic Detox Dosage Level 2:
    Days "On" is typically 5 days per week, usually M-F, but can jump to 10 days

    Morning

    On rising

    2 scoops IMD in 4-6 oz water with 2 pumps Etheric Vitamin C with R-Lipoic Acid

    10-15 min later

    2 or 3 caps Clear Way Cofactors and 2 pumps Etheric Glutathione

    Lunch Time

    30 min before lunch

    2-4 pumps Etheric Vitamin C with R-Lipoic Acid and 2-4 pumps Etheric Glutathione

    Lunch

    Mineral supplements as needed

    Dinner Time

    30 min before dinner

    2 pumps Etheric Vitamin C with R-Lipoic Acid and 2 pumps Etheric Glutathione (or can be done before bed)

    10-15 min later

    2-3 caps Clear Way Cofactors

    Days "Off" is typically 2 days off for Level 2, usually Sat-Sun, but will go to 4 if Days "On" goes to 10

    Take a Multimineral according to directions at full or higher dosage and consider an extra 15-30 mg of Zinc

    Note: All timing blocks are flexible (e.g. If there is fatigue, try taking the "On rising" supplements at night.). If Clear Way gives any upset stomach, take with meals. If taking Rentone, take 2-3 per day in divided doses with meals.



    Quicksilver Therapeutic Detox Dosage Level 3 Intensive:
    Days "On" is typically 10 days. Usually patient does 2-4 cycles like this, but more may be needed for strong clinical response.

    Morning

    On rising

    2 scoops IMD in 4-6 oz water with 4 pumps Etheric Vitamin C with R-Lipoic Acid

    10-15 min later

    2-4 caps Clear Way Cofactors and 3-6 pumps Etheric Glutathione

    Lunch Time

    30 min before lunch

    2-4 caps Clear Way Cofactors, 4-6 pumps Etheric Vitamin C with R-Lipoic Acid and 3-6 pumps Etheric Glutathione

    Lunch

    Mineral supplements as needed

    Dinner Time

    30 min before dinner

    1-2 scoops IMD with 4 pumps Etheric Vitamin C with R-Lipoic Acid (or can be done before bed)

    10-15 min later

    2-4 caps Clear Way Cofactors and 3-6 pumps Etheric Glutathione (or can be done before bed)

    Days "Off" is typically 4 days off for Level 3

    Take a Multimineral according to directions at full or higher dosage and consider an extra 15-30 mg of Zinc

    Note: All timing blocks are flexible (e.g. If there is fatigue, try taking the "On rising" supplements at night.). If Clear Way gives any upset stomach, take with meals. If taking Rentone, take 2-3 per day in divided doses with meals.



    Research Links:  PLEASE NOTE INFO ON ALL THESE TOPICS CAN BE FOUND UNDER THE TAB CALLED 'ALL BROCHURES & PRODUCT SHEET AVAILABLE AT THIS TIME'

    Additional information on IMD Detox Protocol
    Pre-Amalgam Removal Instructions
    QS Pre-tox Protocols
    QS Therapeutic Detox Protocols
    QS IMD Instructions
    QS Kidney Protocols
    QS Dosage Protocols Levels 1, 2, & 3

    Warnings:

    If pregnant or lactating, consult your physician before taking this product
    Keep out of reach of children
    Do not exceed recommended dose

    References:

    1.  Kwak, M-K., Wakabayashi, N., Kensler, T.W., Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutation Research, 2004, 555, 133-148. 
    2.  Mahesh, R., Bhuvana, S., Begum, V.M.H., Effect of Terminalia Chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats. Cell Biochemistry and Function 2009, 27, 358-363. 
    3.  Dvorakova M et aI., The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD). Redox Rep 2006,11 (4): 163-72. 


    * These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.


    GLUTATHIONE
    Mercury Detox Supplements : Glutathione
    Glutathione is one of our best-selling mercury detox supplements. It's the body's master detoxifier and our main antioxidant—and supplementing it supports healthy cellular function. Toxins become linked to glutathione, which then carries them into the bile and the stool, and out of the body. It protects each cell's delicate chemical machinery and helps energy metabolism run efficiently. Glutathione is also integral to the immune system, especially for resistance to viruses. Absorption of glutathione by typical oral delivery is greatly inhibited by breakdown in the stomach. The tiny particles of our liposomal Glutathione greatly enhance absorption. 

    Glutathione Mercury Detox Supplements
       
    Master Detoxifier & Anti-Oxidant 

    Quicksilver Scientific Etheric Delivery TM  Phospholipid Encapsulation System  with Sunflower-Derived Phospholipids 

    1.7 oz, Precision Pump-top
     

    Quicksilver’s Phospholipid Encapsulation Etheric Delivery™ protects the glutathione from digestive enzymes that otherwise prevent absorption of oral glutathione supplementation. In cell cultures, liposomal products have demonstrated over 100 times more efficiency for intracellular delivery than IV-based glutathione.

    Quicksilver Scientific Etheric Delivery™ Glutathione comes with a precision pump to accurately deliver 50 mg of reduced glutathione and 68 mg of injectable-grade essential phospholipids per pump. The patent-pending process, plus our natural lemon flavoring, allows this product to be taken intra-orally for maximum absorption without the foul sulfur taste typical of liposomal glutathione products. Product can be dosed every 3-4 hours for even delivery throughout the day. Each bottle delivers 100, 0.5-ml doses.

    Quicksilver’s Etheric Delivery™ Phospholipid Encapsulation System  brings the power of intravenous therapy into a convenient oral delivery. Our Etheric Delivery™improves upon liposomal technology with smaller, more stable, single-layer spheres made from the highest-grade ingredients available. In addition to exceptional absorption rates, nanospheres like Quicksilver’s have demonstrated the ability to cross the blood-brain barrier, deposit their cargo intracellularly and enter lymphatic circulation. Additionally, the phospholipids that compose the liposome shell feed the cell membranes. This ensures proper function for the absorption of nutrients and the excretion of cellular waste products and toxins.
    Suggested Usage: For general antioxidant and detoxification protection, use 8 pumps per day (400mg Glutathione). For advanced protection, use up to 20 per day (1000mg Glutathione) or more, in divided doses throughout the day. For large doses, take 2 pumps at a time to allow for maximum oral absorption, and hold at least 30 seconds before swallowing. Children should start at ~1/4 of adult (2 pumps per day) dosage and work up. 

    Production Technology Features:

          Tightly controlled small sizing, verified by Laser Dynamic Light Scattering on each batch of Glutathione 

      Flavored with essential oils, giving pleasant citrus taste, suitable for intra-buccal delivery

      Precise Pump Delivery

      Easy Water Dispersability when desired

    Benefits:

     Intraoral delivery for best systemic availability

      Easy to dispense and take directly from bottle

      Excellent for topical use: for application to cold sores or other viral lesions.


    VITAMIN C with R-LIPOIC ACID
    The Cornerstone of Health—Phase II Detox Upregulator

         
     

    Quicksilver Scientific’s Etheric Delivery™ Vitamin C w/ R-Lipoic Acid is the most absorbable form of professional-grade Vitamin C. Vitamin C is essential to any detoxification program because it feeds the system that eliminates toxins. It is also very effective in removing lead and other heavy metals from our system and fighting off the free radicals that form in the liver during the first phase of detoxification. 

    R-Lipoic acid (as sodium R-Lipoate) has an exceptionally well-documented ability to upregulate the glutathione system via the Nrf2 nuclear transcription pathway. This combination of Vitamin C and R-Lipoate in a nanoliposomal delivery potently harnesses the potential of Vitamin C to the power of a fully functioning glutathione system.

    The absorption of conventional oral Vitamin C diminishes rapidly as the dose increases (e.g., ~19% for 1000 mg oral vitamin C). Nanosphere delivery greatly increases absorption and for some compounds can provide higher intracellular delivery than an IV!


    Quicksilver’s Etheric Delivery™ Phospholipid Encapsulation System improves upon liposomal technology with smaller, more stable, single-layer spheres made from the highest-grade ingredients available. In addition to exceptional absorption rates, the nanospheres that Quicksilver produces have demonstrated the ability to cross the blood-brain barrier, deposit their cargo intracellularly and enhance lymphatic circulation of nutrients. Additionally, the phospholipids that compose the liposome shell feed the cell membranes. This ensures the proper function for the absorption of nutrients and the excretion of cellular waste products and toxins.

    Quicksilver’s Etheric Delivery™ Phospholipid Encapsulation System brings the power of intravenous therapy into a convenient oral delivery. 

    Production Technology Features:

    Tightly controlled small sizing, verified by Laser Dynamic Light Scattering on each batch. Flavored with essential oils, giving pleasant citrus taste, suitable for intra-buccal delivery.
    Mean size 50-100nm
    Precise pump delivery
    Easy water dispersability when desired
    Benefits:

    Intraoral delivery for best systemic availability
    Easy to dispense and take directly from bottle
    Other uses beyond detoxification:
    Immune support during cold and flu season
    Vitamin C and R-lipoate stimulate fibroblast activity to support collagen production from topical skin application.
    General Suggested Usage: 

    General use of product for antioxidant and detoxification function, use 8 pumps per day (1000mg of Vitamin C and 50mg of R-Lipoate). For advanced intermittent use, use up to 50 pumps per day (6250mg Vitamin C and 312.5mg R-Lipoate) or more, in divided doses throughout the day. For detoxification protocols, especially with metal toxicities, build dosage gradually, starting from low doses, as they are tolerated. If strong detox reactions are observed, back off dosage. Children should start at ~1/4 of adult (2 pumps per day) dosage and work up. For topical application, one pump can cover the face for a daily treatment, or use several pumps as a mask and leave on for 10-15 minutes; skin can be re-wetted and left for another 10 minutes before rinsing off excess.


    GLUTATHIONE
    Mercury Detox Supplements : Glutathione
    Glutathione is one of our best-selling mercury detox supplements. It's the body's master detoxifier and our main antioxidant—and supplementing it supports healthy cellular function. Toxins become linked to glutathione, which then carries them into the bile and the stool, and out of the body. It protects each cell's delicate chemical machinery and helps energy metabolism run efficiently. Glutathione is also integral to the immune system, especially for resistance to viruses. Absorption of glutathione by typical oral delivery is greatly inhibited by breakdown in the stomach. The tiny particles of our liposomal Glutathione greatly enhance absorption. 

    Glutathione Mercury Detox Supplements
       
    Master Detoxifier & Anti-Oxidant 

    Quicksilver Scientific Etheric Delivery TM  Phospholipid Encapsulation System  with Sunflower-Derived Phospholipids 

    1.7 oz, Precision Pump-top
     

    Quicksilver’s Phospholipid Encapsulation Etheric Delivery™ protects the glutathione from digestive enzymes that otherwise prevent absorption of oral glutathione supplementation. In cell cultures, liposomal products have demonstrated over 100 times more efficiency for intracellular delivery than IV-based glutathione.

    Quicksilver Scientific Etheric Delivery™ Glutathione comes with a precision pump to accurately deliver 50 mg of reduced glutathione and 68 mg of injectable-grade essential phospholipids per pump. The patent-pending process, plus our natural lemon flavoring, allows this product to be taken intra-orally for maximum absorption without the foul sulfur taste typical of liposomal glutathione products. Product can be dosed every 3-4 hours for even delivery throughout the day. Each bottle delivers 100, 0.5-ml doses.

    Quicksilver’s Etheric Delivery™ Phospholipid Encapsulation System  brings the power of intravenous therapy into a convenient oral delivery. Our Etheric Delivery™improves upon liposomal technology with smaller, more stable, single-layer spheres made from the highest-grade ingredients available. In addition to exceptional absorption rates, nanospheres like Quicksilver’s have demonstrated the ability to cross the blood-brain barrier, deposit their cargo intracellularly and enter lymphatic circulation. Additionally, the phospholipids that compose the liposome shell feed the cell membranes. This ensures proper function for the absorption of nutrients and the excretion of cellular waste products and toxins.
    Suggested Usage: For general antioxidant and detoxification protection, use 8 pumps per day (400mg Glutathione). For advanced protection, use up to 20 per day (1000mg Glutathione) or more, in divided doses throughout the day. For large doses, take 2 pumps at a time to allow for maximum oral absorption, and hold at least 30 seconds before swallowing. Children should start at ~1/4 of adult (2 pumps per day) dosage and work up. 

    Production Technology Features:

          Tightly controlled small sizing, verified by Laser Dynamic Light Scattering on each batch of Glutathione 

      Flavored with essential oils, giving pleasant citrus taste, suitable for intra-buccal delivery

      Precise Pump Delivery

      Easy Water Dispersability when desired

    Benefits:

     Intraoral delivery for best systemic availability

      Easy to dispense and take directly from bottle

      Excellent for topical use: for application to cold sores or other viral lesions.