Calm G , CP, PRT  by NeuroScience
Calm G , CP, PRT by NeuroScience

Calm G , CP, PRT by NeuroScience

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Part Number:NS0022-2

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Choose Options

Calm Family Options
Calm G Strong glutamate inhibitor 90 Capsules [+$66.00]
Calm CP Cortisol-focused calming support 60 Capsules [+$58.00]
Calm PRT Adrenal-hyperactivity calming support 60 Capsules [+$102.00]

Calm G

Contains a blend of ingredients important for regulating glutamate activity, stress-reduction, metabolic health, and mitochondrial function*

Key ingredients
N-acetyl-L-cysteine: Precursor to L-cysteine (1). L-cysteine is required for the synthesis of glutathione, an endogenous antioxidant important for mediating oxidative stress (2).

L-theanine: Amino acid that acts as a glutamate receptor antagonist (3).* Glutamatergic signaling underlies mechanisms related to anxiousness and stress (4). In a double-blind, placebo-controlled study, L-theanine was shown to significantly reduce stress (5).*

Alpha-lipoic acid: Antioxidant that is able to regenerate endogenous antioxidants and scavenge metal ions and free radicals (6).* Evidence suggests the insulin-signaling pathway is sensitive to redox status (6). Alpha-lipoic acid can influence the redox status in cells important for the translocation of glucose transporters and increasing glucose uptake (6).*

Coenzyme Q10: Compound found in nearly every human cell that is essential for mitochondrial function and antioxidant protection (7).*

References

  1. Rushworth G and Megson I. Pharmacol Ther. 2014;141(2):150-9.
  2. Schmitt B, et al. Redox Biol. 2015;6:198-205.
  3. Kakuda T, et al. Biosci Biotechnol Biochem. 2002;66(12):2683-6.
  4. Bermudo-Soriano C, et al. Pharmacol Biochem Behav. 2012;100(4):752-74.
  5. Kimura K, et al. Biol Psychol. 2007;74(1):39-45.
  6. Rochette L, et al. Can J Physiol Pharmacol. 2015;93(12):1021-7.
  7. Garrido-Maraver J, et al. Front Biosci (Landmark Ed). 2014;19:619-33.

Label Details

Servings Per Container: 45

Take 1-2 capsules three to four times daily or as directed by your healthcare provider.


Serving Size: 2 Capsules

Amount Per Serving
Folate ... 150mcg
(from (6S)-5-methyltetrahydrofolic acid, glucosamine salt**)
Selenium ... 70mcg
(as L-selenomethionine)
Proprietary Blend ... 1.1g
N-acetyl-L-cysteine, L-theanine, Alpha-lipoic acid, and Coenzyme Q10

Other Ingredients: Microcrystalline cellulose, Vegetable capsule (Hypromellose, water), and Magnesium stearate (vegetable source).

**This product uses Gnosis S.p.As (6S)-5-methyltetrahydrofolic acid, glucosamine salt (Quatrefolic®) and is protected by U.S. Patent No. 7, 947, 662. Quatrefolic is a registered trademark of Gnosis S.p.A., Milan, Italy.

Notes

If you are pregnant or nursing, consult your healthcare provider before use.


Calm PRT
decreases norepinephrine and contains ingredients important for regulating the stress response, sleep, and reducing anxiousness.* Many products claim to contain sizable amounts of Rhodiola but use lower standardizations of rosavins, resulting in low amounts of rosavins in the product. Calm PRT delivers 112.5mg of rosavins per serving, more than triple the closest competitor from a meta-analysis of public formulas, and provides significant results for patients with poorly managed stress and anxiousness.* Calm PRT has also demonstrated in two meta-analyses to significantly decrease norepinephrine (91 people; p<0.01) and significantly decrease evening cortisol (106 people; p<0.01).*


Key ingredients
Rhodiola rosea root extract (standardized to 9% rosavins, providing 112.5 mg of rosavins): Adaptogen shown to reduce anxiousness and stress-related effects (1,2).*

Phosphatidylserine: Component of cell membranes important for receptor-mediated interactions (3).* Phosphatidylserine is thought to interact with cell membranes in order to dampen hypothalamic signaling and regulate the stress response (4).*

Glycine: Major inhibitory neurotransmitter that crosses the blood-brain barrier (5).* Binds receptors that regulate temperature during sleep (6).*

Taurine: Neuroprotective amino acid that provides antioxidant protection and demonstrates GABA-A agonist activity (7-9).* GABA is the primary inhibitory neurotransmitter in the brain important for calm and sleep (10-12).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References

  1. Bystritsky A, et al. J Altern Complement Med. 2008;14(2):175-80.
  2. Olsson E, et al. Planta Med. 2009;75(2):105-12.
  3. Monteleone P, et al. Eur J Clin Pharmacol. 1992;41:385-8.
  4. Glade M and Smith K. Nutrition. 2015;31(6):781-6.
  5. Kawai N, et al. Amino Acids. 2012;42(6):2129-37.
  6. Kawai N, et al. Neuropsychopharmacology. 2015;40(6):1405-16.
  7. Kumari N, et al. Adv Exp Med Biol. 2013;775:19-27.
  8. Shimada K, et al. Adv Exp Med Biol. 2015;803:581-96.
  9. Kletke O, et al. PLoS One. 2013;8(4):e61733.
  10. Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
  11. Mohler H. Neuropharmacology. 2012;62(1):42-53.
  12. Saper C, et al. Nature. 2005;437(7063):1257-63.


Servings Per Container: 22
Take 3-4 capsules one to two times daily or as directed by your healthcare provider. Do not exceed suggested use.


Serving Size: 4 Capsules

Amount Per Serving
Proprietary Blend ... 2g
Rhodiola rosea root extract (standardized to 9% rosavins, providing 112.5 mg of rosavins), Phosphatidylserine enriched soy lecithin**), Glycine, and Taurine.

Other Ingredients: Microcrystalline cellulose, Vegetable capsule (Hypromellose, water), Silicon dioxide, and Magnesium stearate (vegetable source).

Contains lecithin from soy.

**This product uses SerinAid® 50P (Phosphatidylserine enriched soy lecithin). SerinAid® is a registered trademark of Chemi Nutra.


If you are pregnant or nursing, consult your healthcare provider before use.


Calm CP

Decreases cortisol levels and provides ingredients important for calm, sleep, and management of blood sugar*

Lagerstroemia speciosa (Banaba) leaf extract (2% corosolic acid): Corosolic acid selectively inhibits 11ß-hydroxysteroid dehydrogenase 1 (11ß-HSD1), an enzyme that catalyzes the conversion of cortisone into cortisol (1, 2).* In a randomized study, corosolic acid was shown to significantly lower blood glucose levels by 20-30% after two weeks (3).*

Phosphatidylserine: Component of cell membranes important for receptor-mediated interactions (4).* Phosphatidylserine is thought to interact with cell membranes in order to dampen hypothalamic signaling and regulate the stress response (5).*

Glycine: Major inhibitory neurotransmitter that crosses the blood-brain barrier (6).* Binds receptors that regulate temperature during sleep (7).*

Taurine: Neuroprotective amino acid that provides antioxidant protection and demonstrates GABA-A agonist activity (8-10).* GABA is the primary inhibitory neurotransmitter in the brain important for calm and sleep (11-13).

References

  1. Rollinger J, et al. Bioorg Med Chem. 2010;18(4):1507-15.
  2. Patel H, et al. Arabian Journal of Chemistry. 2015.
  3. Judy W, et al. J Ethnopharmacol. 2003;87(1):115-7.
  4. Monteleone P, et al. Eur J Clin Pharmacol. 1992;41:385-8.
  5. Glade M and Smith K. Nutrition. 2015;31(6):781-6.
  6. Kawai N, et al. Amino Acids. 2012;42(6):2129-37.
  7. Kawai N, et al. Neuropsychopharmacology. 2015;40(6):1405-16.
  8. Kumari N, et al. Adv Exp Med Biol. 2013;775:19-27.
  9. Shimada K, et al. Adv Exp Med Biol. 2015;803:581-96.
  10. Kletke O, et al. PLoS One. 2013;8(4):e61733.
  11. Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
  12. Mohler H. Neuropharmacology. 2012;62(1):42-53.
  13. Saper C, et al. Nature. 2005;437(7063):1257-63.

Label Details

Servings Per Container: 30
Servings Per Container: 30

Take 2 capsules one to two times daily or as directed by your healthcare provider.


Serving Size: 2 Capsules

Amount Per Serving
Proprietary Blend ... 1.2g
Lagerstroemia speciosa (Banaba) leaf extract (2% corosolic acid), Phosphatidylserine, enriched soy lecithin**), Glycine, and Taurine.

Other Ingredients: Vegetable capsule (Hypromellose, water), Microcrystalline cellulose, Magnesium stearate (vegetable source), and Silicon dioxide.

**This product uses SerinAid® 50P (Phosphatidylserine enriched soy lecithin). SerinAid® is a registered trademark of Chemi Nutra.

Contains lecithin from soy.

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