Bio-B12 by Thorne Research
New Formula, now with 5-MTHF – the active form of folate!

Bio-B12 by Thorne Research

Your Price: $17.25
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Part Number:6851

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Consultation for first time customers interested in purchasing this Brand of Products is required. Please call during office hours - 561-337-9435 (an initial 10 min consultation is complimentary)
IF you already have a prescribing practitioner, please have your practitioner send a note authorizing purchase to: Dr. Hale, AP at [email protected] or fax: 855-486-6426
If you do not have a prescribing practitioner, then Dr. Hale, AP will be glad to be of assistance.
This is a professional brand product and as such there are internet sales restrictions per the manufacturer's policies.

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Dr Hale, AP
New Formula, now with 5-MTHF – the active form of folate!
  • with methylcobalamin and 5-MTHF, the biologically active, tissue-ready forms of B12 and folate
  • papain, an enzyme from papaya, aids absorption
  • zinc supports the pancreas – important for absorption
  • a viable option to sublingual B12 products
In order for vitamin B12 to be absorbed in the gastrointestinal tract, it first needs to be bound in the stomach to a protein called R-protein. In the intestines pancreatic proteases cause the R-protein to release vitamin B12 to bind with intrinsic factor, making it absorbable. Thorne Researchs Bio-B12 contains methylcobalamin (an active form of vitamin B12) and 5-MTHF (an active form of folate) in a base of papain. Papain is a potent protein-digesting enzyme from papaya that also results in the release of vitamin B12 from the R-protein, thus facilitating the absorption process.* Zinc picolinate is included for support of the pancreas, which produces other digestive enzymes that facilitate the absorption process.*
Methylcobalamin (an active form of vitamin B12) is essential for recycling homocysteine and the formation of methyl donors involved in cardiovascular function, sleep, blood cell formation, and nerve function.* Most vitamin B12 supplements contain cyanocobalamin; however, the liver must first "detoxify" the cyanide molecule and attach a methyl group to form methylcobalamin from the cyanocobalamin. Methylcobalamin is already in the biologically active, tissue-ready form.* Evidence indicates the body utilizes methylcobalamin more efficiently than it does cyanocobalamin.* Research shows the quantity of cobalamin detected following a small oral dose of methylcobalamin is similar to the amount following administration of cyanocobalamin; but significantly more cobalamin accumulates in liver tissue following administration of methylcobalamin. Human urinary excretion of methylcobalamin is about one-third that of a similar dose of cyanocobalamin, indicating substantially greater tissue retention.*


Servings Per Container: 60 
Take 1 capsule one to three times daily or as recommended by a health-care practitioner.

Serving Size: 1 Capsule
Amount Per Serving
Vitamin B12 ... 1mg
(as Methylcobalamin)
Folate ... 800mcg
(as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)
Zinc ... 15mg
(as Zinc Picolinate)
Papain†† ... 75mg
Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Silicon Dioxide.
†This product uses Gnosis S.p.A.’s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt (Quatrefolic®). Quatrefolic is a registered trademark of Gnosis S.p.A.
††An enzyme derived from Papaya (Carica papaya).