New Formula, now with 5-MTHF – the active form of folate!
- with methylcobalamin and 5-MTHF, the biologically active, tissue-ready forms of B12 and folate
- papain, an enzyme from papaya, aids absorption
- zinc supports the pancreas – important for absorption
- a viable option to sublingual B12 products
In order for vitamin B12 to be absorbed in the gastrointestinal tract, it first needs to be bound in the stomach to a protein called R-protein. In the intestines pancreatic proteases cause the R-protein to release vitamin B12 to bind with intrinsic factor, making it absorbable. Thorne Researchs Bio-B12 contains methylcobalamin (an active form of vitamin B12) and 5-MTHF (an active form of folate) in a base of papain. Papain is a potent protein-digesting enzyme from papaya that also results in the release of vitamin B12 from the R-protein, thus facilitating the absorption process.* Zinc picolinate is included for support of the pancreas, which produces other digestive enzymes that facilitate the absorption process.*
Methylcobalamin (an active form of vitamin B12) is essential for recycling homocysteine and the formation of methyl donors involved in cardiovascular function, sleep, blood cell formation, and nerve function.* Most vitamin B12 supplements contain cyanocobalamin; however, the liver must first "detoxify" the cyanide molecule and attach a methyl group to form methylcobalamin from the cyanocobalamin. Methylcobalamin is already in the biologically active, tissue-ready form.* Evidence indicates the body utilizes methylcobalamin more efficiently than it does cyanocobalamin.* Research shows the quantity of cobalamin detected following a small oral dose of methylcobalamin is similar to the amount following administration of cyanocobalamin; but significantly more cobalamin accumulates in liver tissue following administration of methylcobalamin. Human urinary excretion of methylcobalamin is about one-third that of a similar dose of cyanocobalamin, indicating substantially greater tissue retention.*
Servings Per Container: 60
Take 1 capsule one to three times daily or as recommended by a health-care practitioner.
Serving Size: 1 Capsule
Amount Per Serving
Vitamin B12 ... 1mg
Folate ... 800mcg
(as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)
Zinc ... 15mg
(as Zinc Picolinate)
Papain†† ... 75mg
Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Silicon Dioxide.
†This product uses Gnosis S.p.A.’s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt (Quatrefolic®). Quatrefolic is a registered trademark of Gnosis S.p.A.
††An enzyme derived from Papaya (Carica papaya).