8:00 A.M. Baseline blood draw
40 sprays-ACG Glutathione 8:30 A.M., 10:30 A.M., 12:30 P.M., 2:30 P.M.
4:00 P.M. 7 hour blood draw
EDTA tubes were refrigerated. Baseline and 7 hour draw blood samples were drawn and shipped to the lab same day.
SCIENCE
GSH IS CRITICAL IN MANY CELLULAR REACTIONS
Key Points
GSH reacts with various physiological metabolites such as, estrogen, prostaglandins, leukotrienes, and chemicals, such as bromobenzene and counteracts acetaminophen overdose
GSH interacts with Nitric oxide and both have critical roles regulating lipids, glucose, and amino acid utilization
GSH is involved with the removal of the carcinogen, Formaldehyde, from the body
GSH is required for the prostaglandin H2 pathways
GSH inhibits Influenza virus infection
GSH is involved in many other important metabolic pathways, including protein metabolism
GSH is required for the proliferation of cells, including lymphocytes and intestinal epithelial cells
GSH plays an important role in spermatogenesis and sperm maturation
GSH is essential for the activation of T-lymphocytes and polymorphonuclear leukocytes, and is required for cytokine production. GSH is important for successful immune responses when the host is immunologically challenged
GSH is involved in the process of maintaining Vitamin C and E in the active metabolic forms
LITERATURE CITED
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Guoyao Wu2, Yun-Zhong Fang, Sheng Yang, Joanne R. Lupton, and Nancy D. Turner. (2004) Glutathione Metabolism and Its Implications for Health. Am. Soc. Nut. Sci.
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Badaloo, A., Reid, M., Forrester, T., Heird, W. C. & Jahoor, F. (2002) Cysteine supplementation improves the erythrocyte glutathione synthesis rate in children with severe edematous malnutrition. Glutathione Metabolism and Its Implications for Health.Am. J. Clin. Nutr. 76:646-652.
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Griffith, O. W. (1999) Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic. Biol. Med. 27:922-935.
Canals, S., Casarejos, M. J., de Bernardo, S., Rodriguez-Martin, E. & Mena, M. A. (2003) Nitric oxide triggers the toxicity due to glutathione depletion in midbrain cultures through 12-lipoxygenase. J. Biol. Chem. 278:21542-21549.
Johnson, A. T., Kaufmann, Y. C., Luo, S., Todorova, V. & Klimberg, V. S. (2003) Effect of glutamine on glutathione, IGF-1, and TGF-β1. J. Surg. Res. 111:222-228.
Fang, Y. Z., Yang, S. & Wu, G. (2002) Free radicals, antioxidants, and nutrition. Nutrition 18:872-879.
Lei, X. G. (2002) In vivo antioxidant role of glutathione peroxidase: evidence from knockout mice. Methods Enzymol. 347:213-225.
Cai, J., Chen, Y., Seth, S., Furukawa, S., Compans, R. W. & Jones, D. P. (2003) Inhibition of influenza infection by glutathione. Free Radic. Biol. Med. 34:928-936.
